產(chǎn)品詳情

  • 產(chǎn)品名稱：SCH-529704

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
SCH-529704
詳情介紹：
Characteristics

PubChem CID: 12001922
Molecular Formula: C??H??Cl?N?
Cell Premeable: Yes

Salt form: No

SCH-529074 is a small molecule activator of mutant p53. It binds specifically to the p53 DBD (DNA binding domain) in a saturable manner with an affinity of 1-2 μM. Binding restores wild type function to many oncogenic mutant forms of p53. SCH-529074 reactivates mutant p53 by acting as a chaperone. In addition to reactivating mutant p53, SCH-529074 binding inhibits ubiquitination of p53 by HDM2.

Smiles: CN(C)CCCNC1=NC(=NC2=CC=CC=C21)CN3CCN(CC3)C(C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

InChi: InChI=1S/C31H36Cl2N6/c1-37(2)17-5-16-34-31-27-6-3-4-7-28(27)35-29(36-31)22-38-18-20-39(21-19-38)30(23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h3-4,6-15,30H,5,16-22H2,1-2H3,(H,34,35,36)

Inchi Key: NCAJLQDPTZBGJV-UHFFFAOYSA-N
Purity ≥ 98?%
Chemical Name N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine
Formula C??H??Cl?N?
Permeability Cell-permeable
Background Synonyms: N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine
Molecular Weight 563.56 g/mol
CAS-No 922150-11-6
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months