產(chǎn)品詳情

  • 產(chǎn)品名稱：Zosuquidartrihydrochloride

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Zosuquidartrihydrochloride
詳情介紹：
Characteristics

PubChem CID: 153997
Molecular Formula: C??H??FN?O.3HCl
Cell Premeable: Yes

Salt form: N/A

Zosuquidar is a potent P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Zosuquidar binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). Restores doxorubicin (Cat. No. 1527) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines.

Smiles: C1CN(CCN1CC(COC2=CC=CC3=C2C=CC=N3)O)C4C5=CC=CC=C5C6C(C6(F)F)C7=CC=CC=C47.Cl.Cl.Cl

InChi: InChI=1S/C32H31F2N3O2.3ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27,/h1-14,21,29-31,38H,15-20H2,3*1H/t21-,29-,30+,31?,/m1.../s1

Inchi Key: ZPFVQKPWGDRLHL-ZLYBXYBFSA-N
Purity ≥ 98?% by HPLC
Chemical Name (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride; LY335979
Formula C??H??FN?O.3HCl
Permeability Cell-permeable
Background Synonyms: (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride, LY335979
Molecular Weight 636.99 g/mol
CAS-No 167465-36-3
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 36 months