產(chǎn)品詳情

  • 產(chǎn)品名稱：Linsitinib,Freebase

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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Linsitinib,Freebase
詳情介紹：
Characteristics A potent, small-molecule dual insulin-like growth factor-1 receptor (IGF-1R)/insulin receptor (IR) kinase inhibitor. Inhibits IGF-1R and IR kinases with IC50values of 35 nM and 75 nM, respectively. Linsitinib selectively blocks the autophosphorylation of both human IGF-1R and IR, inhibits the proliferation of a variety of tumor cell lines in vitro, and displays robust in vivo anti-tumor efficacy in an IGF-1R-driven xenograft model when administered orally.
Purity ≥ 99?% by HPLC
Chemical Name (1S,3S)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol; OSI-906; OSI 906AA
Formula C??H??N?O
Permeability Cell-permeable
Molecular Weight 421.49 g/mol
CAS-No 867160-71-2
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months
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image for Linsitinib, Free base (ABIN1685606) Linsitinib, Free base