產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：KN-93

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
KN-93
詳情介紹：
Purpose A potent inhibitor of Ca2+/calmodulin-dependent kinase type II
Characteristics White solid
Molecular formular: C26H29ClN2O4S
Purity ≥ 98?%
Chemical Name N-?[2-?[[[3-?(4-?chlorophenyl)-?2-?propen-?1-?yl]methylamino]methyl]phenyl]-?N-?(2-?hydroxyethyl)-?4-?methoxy-?benzenesulfonamide
Formula C??H??ClN?O?S
Permeability Cell-permeable
Molecular Weight 501.04 g/mol
CAS-No 139298-40-1
Comment

Synonyms:
KN-93
Cell-permeable.
KN-93 is a potent inhibitor of Ca2+/calmodulin-dependent kinase type II (CaM kinase II) (IC = 0.37 M). It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase. Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC = 307 nM for Kv1.5). More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for KN-93 (ABIN1889071) KN-93