產(chǎn)品詳情

  • 產(chǎn)品名稱：alpha-conotoxinIMI(alphaconotoxinIMI)

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Smartox-Biotech
  • 產(chǎn)品文檔：
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簡單介紹：
alpha-conotoxinIMI(alphaconotoxinIMI)
詳情介紹：
Purpose alpha-conotoxin IMI blocks nAChR
Sequence Gly-Cys2-Cys3-Ser-Asp-Pro-Arg-Cys8-Ala-Trp-Arg-Cys12-NH2Disulfide bonds between Cys2-Cys8 and Cys3-Cys12
Background Alpha-conotoxin IMI has been isolated from the venom of the cone snail Conus mperialis. alpha-conotoxin IMI acts on postsynaptic membranes, and binds onto and inhibits nicotinic acetylcholine receptors (nAChR). This toxin blocks mammalian neuronal nAChRs (alpha3/?2 > alpha7 > alpha3/?4). It has no effect on nAChRs composed of alpha2/?2, alpha3/?2, alpha4/?2, alpha2/?4, alpha3/?4, or alpha4/?4 subunits. alpha-conotoxins IMI acts independently of voltage value. This toxin is highly active against the neuromuscular receptor in frog.
Molecular Weight 1352.92 Da
CAS-No 156467-85-5
Restrictions For Research Use only